Plant-based bioproduction

Exploiting the full potential of plants to make them a simple, robust bioproduction platform with a low environmental footprint.

From plants to product

  • Molecular engineering to design the protein or metabolite that will provide the best response to the targeted need.
  • An ideal plant for bioproduction. Non-food and not for agricultural use, N. benthamiana grows quickly, can be grown without pesticides and is ready to produce in just 30 days.
  • Optimized growing conditions to maximize the potential of each plant as a bioproduction unit.

  • A transient expression technology that allows for rapid and highly productive production, in a safe working environment, without maintaining transgenic plants, without handling live viruses.
  • Tailor-made extraction and purification processes, based on product properties and industry standards.
  • Vertical cultivation facilities and controlled and automated environment for a reproducible bioproduction model, guaranteeing consistent quality that can be deployed anywhere in the world and with significant advantages on the environmental footprint.

Molecular engineering

  • Targeted engineering using various modeling tools
  • High-throughput screening platform to test and validate a large number of candidates in parallel.
  • Ability to adapt expression levels according to the required yields thanks to multiple molecular tools.
  • Ability to express multiple proteins simultaneously and thus provide the ability to recreate entire metabolic pathways and product combinations unique to plants.

Model plant

The plant used by Aramis, N. benthamiana, is a world reference in plant bioproduction thanks to a unique combination of assets. The laboratory variety known as “LAB” is the most widely used in bioproduction and has been since the 1990s. It is particularly well suited to the infiltration process, which allows for rapid transient expression and high yields. It also benefits from advanced genetic tools and an already well-established industrial ecosystem.

At Aramis, it is produced exclusively in a controlled environment and grown without pesticides. N. benthamiana is neither a field crop nor a food plant. The molecules are expressed in its leaves transiently for only six days, without maintenance of transgenic lines.

The plant-based bioproduction carried out by Aramis therefore does not present any risk of cross-contamination with the food chain and does not compete with agriculture; on the contrary, it opens up new outlets with high added value.

Extraction and purification processes

Tailored to every product and market

  • 1

    A wide variety of processes

    Thanks to decades of innovation in the fields of agri-food, natural products and pharmaceuticals, a wide range of extraction and purification technologies is now available to efficiently valorize the molecules produced in plants.

  • 2

    Adapted and innovative technologies

    Aramis develops proprietary technologies specifically designed to optimize the plant-based bioproduction value chain. Among them, an innovative enzymatic digestion approach improves extraction yield while ensuring product quality.

  • 3

    Unique know-how and expertise

    With many years of experience in plant-based bioproduction, the Aramis team masters the development of efficient extraction and purification processes. This expertise makes it possible to adapt each process to the characteristics of the targeted product while meeting the quality, yield and cost requirements of the various industries.

  • 4

    Demonstrated at commercial scale

    The Aramis team is one of the few that has successfully scaled up bioproduction plant-based processes from the laboratory stage to commercial industrial production. This unique experience covers the entire development path, from process optimization to large-scale deployment.

Infrastructure and Capabilities

  • Located in Quebec City, Aramis has 5,300 square meters of facilities including production, R&D laboratories and administration.
  • Industrial manufacturing capacity to support Phase 1 to 3 clinical studies and pharmaceutical commercial production. These facilities include:
    • A controlled and highly automated vertical farming biomass production facility.
    • A pharmaceutical extraction and purification facility.

Local innovation

Based in Quebec City, Canada, Aramis Biotechnologies promotes unique scientific know-how by relying on a dynamic local ecosystem. We innovate, develop and produce biosolutions rooted here and designed to generate an international impact.